Tsc1fl/fl
Web005680 STOCK Tsc1 tm1Djk /J These floxed mutant mice possess loxP sites flanking exons 17 and 18 of the Tsc1 gene. This mutant strain may be useful in tissue-specific studies … WebSep 6, 2012 · In parallel, (tuberous sclerosis complex 1) TSC1fl/fl neurons were transduced with iCre-RFP lentivirus to knock out TSC1 in mouse cortical neurons to increase mTOR activation and generate an in vitro model of cytomegalic neurons. The TSC1 and pS6 protein staining was used to identify TSC1 knockout (TSC1-/-) neurons.
Tsc1fl/fl
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WebFeb 6, 2024 · Control mice were injected with 1 × 10^9 PFU of adenovirus serotype 5 expressing GFP only: Tsc1fl/fl. b Plasma insulin levels of insulin-deficient mice and healthy controls (p = 0.0003 and p = 0.0001). C mRNA content of Tcs1 in liver (p = 0.0584) and skeletal muscle (gastrocnemius) of the indicated groups. (Credit: University of Geneva … WebJun 13, 2024 · BMMs from Tsc1fl/fl mice were retrovirally infected with Cre recombinase, and subsequent stimulation with RANKL, followed by actin ring formation assay (n = 3). …
WebNov 1, 2014 · These mice were bred with Tsc1fl/fl to inactivate both Tsc1 alleles by Cre-mediated excision, thereby creating conditional knockout mice in which the Tsc1 gene was specifically disrupted in podocytes (podo-Tsc1−/−, genotype: Tsc1fl/fl, Cre+/−). The breeding protocol also generated heterozygous littermates ... WebLivers of the Ptenfl/fl;AlbCre mice developed steatosis and most of the tumors that formed were intrahepatic cholangiocarcinomas. Livers of Tsc1fl/fl;Ptenfl/fl;AlbCre formed large …
WebPhosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase v-akt murine thymoma viral oncogene homolog 1 (Akt) and mammalian target of rapamycin complex (mTORC1) are effectors of PI3K that promote cell growth and survival, but their individual roles in tumorigenesis are not well …
WebNov 19, 2024 · [Nov. 19, 2024: Marco Cattaneo, Université de Genève] Científicos de la Universidad de Ginebra (UNIGE) trabajan desde hace varios años en una terapia alternativa basada en la proteína S100A9.
WebLivers of the Ptenfl/fl;AlbCre mice developed steatosis and most of the tumors that formed were intrahepatic cholangiocarcinomas. Livers of Tsc1fl/fl;Ptenfl/fl;AlbCre formed large numbers of tumors, of mixed histologies, with the earliest onset of any strain, indicating that loss of Tsc1 and Pten have synergistic effects on tumorigenesis. the palomino glasgowWebJun 13, 2024 · Europe PMC is an archive of life sciences journal literature. shutters to buyWebFeb 3, 2015 · Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protects against high-fat diet induced steatosis. … shutterstock arabic floral frameWebFemale floxed Tsc1 mice (Tsc1FL/FL) containing LoxP sites flanking exons 17 and 18 of the Tsc1 gene were crossed with male osteocalcin (OC)-Cre mice, whose expression of Cre … shutterstock accountWebFigure 2. RGS5 expression is up-regulated in HCC and liver fibrosis. Sections of liver from Tsc1fl/fl;AlbCre (A,C) and Ptenfl/fl;AlbCre (B,D) mice were stained with Masson’s trichrome. A. Tsc1fl/fl;AlbCre non-tumor liver is histologically normal. B. Ptenfl/fl;AlbCre non-tumor liver tissue is steatotic and shows collagen deposition in sinusoids (blue). C. Tsc1fl/fl;AlbCre … shutterstock account for saleWebSearch Results for Animals Tsc1fl Fl Mice on Bioz, providing objective ratings for all products used in life science research. Home > Search Results ... Article Snippet: Mouse: … the palm woods los angelesWebStatus: Public on Aug 30, 2024: Title: The potential biomarkers for HCC patients with functional loss of both p53 and Tsc1: Organism: Mus musculus: Experiment type shutterstock airport