2024 Cytoplasmic sox10

Cytoplasmic sox10

Author: xedt

August undefined, 2024

WebAbstract. SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been … WebIn ARM, cytoplasmic SOX10 was co-expressed with neuronal antigens in ~57% of submucosal and myenteric neurons, vs. ~3% in control. Furthermore, intrinsic gut neurons in ARM specimens co-expressed PLP1 (18%) and CDH19 (18%); however, neuronal co-expression of PLP1 and CDH19 was rarely (<2%) observed in controls.

SOX10 ablation severely impairs the generation of postmigratory neura…

WebJan 10, 2024 · To isolate single Sox10 + /FSP1 − cells from Sox10 + /FSP1 + cells, we plated the mixed cell population at very low density (~100 cells per 100-mm dish), and … WebNov 4, 2024 · SOX10 positivity is also commonly expressed in both mixed tumors and myoepitheliomas (~80%), but is only present in a minor percentage of myoepithelial carcinomas (Fig. 3f) . Other markers of ... geogebra incenter of triangle

Reliability of immunostaining using pan‐melanoma …

WebJun 19, 2024 · In contrast to S100, which is expressed in both the nucleus and cytoplasm, SOX10 is confined to the nucleus, enabling double staining to be performed on paraffin … WebJan 31, 2024 · The majority of tumors demonstrated 1 of 3 distinct patterns: 1) malignant melanomas with nuclear SOX10 (sensitivity of 94% and specificity of 95%); 2) epithelioid/pleomorphic sarcomas negative for … WebSOX10. −: − ± ... The cytoplasm is usually amphophilic and granular due to their secretory content. MTCs routinely express neuroendocrine markers as well as signs of thyroid differentiation (TTF1), whereas monoclonal PAX8 expression is lacking, as is thyroglobulin (the latter a consequence of the non-follicular cell origin). ... geogebra software for windows 7

Fbxo9 functions downstream of Sox10 to determine neuron-glial …

SOX10 is a novel marker of acinus and intercalated …

WebAug 27, 2024 · Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural … WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ... chris on the beachWebThis granular cell tumor shows strong nuclear and cytoplasmic expression in virtually all of the tumor cells. The tumor cells surround a small peripheral nerve , which also expresses … geogebra range of a function

"WebOct 1, 2012 · Sox10 is a marker of neural crest origin and is expressed in melanoma and peripheral nerve sheath tumors. •. This article explores Sox10 expression in various … " - Cytoplasmic sox10

Cytoplasmic sox10

Sox10 is an active nucleocytoplasmic shuttle protein, and ... - PubMed

WebNuclear and cytoplasmic Expression in Normal Tissues [] This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, … WebApr 5, 2013 · Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin, calponin, CK14, CK5/6 and Glial fibrillary acidic protein; both ...

Did you know?

WebA weak cytoplasmic staining reaction in cells with a strong nuclear staining reaction was accepted. Participation Number of laboratories registered for SOX10, run 55 211 Number of laboratories returning slides 204 (97%) Results 204 laboratories participated in this assessment. 181 (89%) achieved a sufficient mark (optimal or good). WebFeb 6, 2024 · We found that Sox10 induced the expression of Fbxo9, which is both required and sufficient for regulating Neurog2 protein stability via ubiquitination that was …

Web方法. 回顾性分析2016年2月至2024年1月上海市肺科医院与复旦大学附属肿瘤医院确诊的5例肺gct的临床资料、病理形态学特征及免疫表型特点，并复习相关文献。 WebNov 29, 2024 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and inter …

WebNordic Immunohistochemical Quality Control, SOX10 run 60 2024 Page 1 of 9 Assessment Run 60 2024 Transcription factor SOX-10 (SOX10) Purpose Evaluation of the technical performance, level of analytical sensitivity and specificity of IHC tests among ... a weak cytoplasmic staining reaction of ganglion/neuronic cells in the appendix was accepted ... WebDec 3, 2024 · SOX10, located at 22q13.1, has five transcripts (splice variants), 67 orthologs, and 16 paralogs. As a nucleocytoplasmic shuttle protein, SOX10 is of great significance to the development of the neural crest, the peripheral nervous system, and melanocytes ( Castillo and Sanchez-Cespedes, 2012 ).

WebApr 4, 2024 · Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2024] Sox10 SRY (sex determining region Y)-box 10 [ (house mouse)] Gene ID: 20665, updated on 4-Apr-2024. Summary. ... and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of …

WebApr 5, 2013 · Appropriate positive and negative controls were used for each antibody. Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin... geogebra software download for windows 10WebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … geogebra theoreme de pythagoreWebAug 11, 2015 · SOX10 was negative in 10 cases of ITACs and 2 cases of non-ITACs, and positive in all other adenocarcinomas. The sensitivity of CK7-, CK20+, SOX10- and CDX2+ in primary ITACs of the sinonasal tract were 70.0%, 90.0%, 100%, 100%, respectively, and the specificity were 100%, 96.8%, 93.5%, 100%, respectively. Conclusions: geogebra software for windows 10WebMar 15, 2024 · SOX10 shows an increased specificity for soft tissue tumors of neural crest origin compared with S100 ( Appl Immunohistochem Mol Morphol 2012;20:445 ) MITF1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with … chris on sopranosWebFeb 6, 2024 · The relocalization of ectopic Neurog2 from the nucleus to the cytoplasm suggests the possibility that overexpression of Sox10 promotes ubiquitination of Neurog2, which could occur in both compartments as evidenced by another short-lived bHLH transcription factor, MyoD ( 26 ). chris on star trekWebJan 1, 2014 · (B) Sox10 immunohistochemistry results in diffuse crisp nuclear staining in all granular tumor cells in cutaneous GCTs, 400×. (C) Noncutaneous GCTs from breast (top) and tongue (bottom), as well as other deep tissue sites, also showed diffuse nuclear staining in all granular tumor cells. chris on the dock breakfast st louisSOX10 is used as an immunohistochemistry marker, being positive in: • Neuroectodermal neoplasms of neural crest origin, especially: Melanoma, although desmoplastic melanomas may be only focally positive. Nevus • SOX10 immunohistochemistry in a dermal nevus, showing positively stainin… geogebra software download for pc